2-Methylpyrimidin-4-amine → 5-Bromo-1-methyl-3-(2-methylpyrimidin-4-ylamino)pyridin-2(1H)-one

HRID 407645

반응식

HRID 407645 반응식
[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][N:3]=1.Br[C:10]1[C:11](=[O:18])[N:12]([CH3:17])[CH:13]=[C:14]([Br:16])[CH:15]=1>>[Br:16][C:14]1[CH:15]=[C:10]([NH:8][C:6]2[CH:5]=[CH:4][N:3]=[C:2]([CH3:1])[N:7]=2)[C:11](=[O:18])[N:12]([CH3:17])[CH:13]=1

참가 물질

3

반응물 2

HCID 2957632-Methylpyrimidin-4-amineHCID 36143503,5-Dibromo-1-methylpyridin-2(1H)-one

생성물 1

HCID 680968835-Bromo-1-methyl-3-(2-methylpyrimidin-4-ylamino)pyridin-2(1H)-one수율 43.4%

실험 절차

Following the procedure in Example 113a, and starting with 2-methylpyrimidin-4-amine (2.0 g, 18.3 mmol) and 3,5-dibromo-1-methylpyridin-2(1H)-one (9.6 g, 36 mmol) afforded 114a as a yellow solid (2.3 g, 43.4%). MS: [M+H]+ 295. 1H NMR (500 MHz, DMSO-d6) δ 9.20 (s, 1H), 8.78 (s, 1H), 8.26 (d, J=4.5 Hz, 1H), 7.68 (s, 1H), 7.18 (d, J=4.5 Hz, 1H), 3.59 (s, 3H), 2.52 (s, 3H).

출처 및 근거

ORD 기록
ord-4df9a43779c14a40831e3dbdadb0fbee
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754077B2

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