Urea → 5,7-dichloroquinazoline-2,4(1H,3H)-dione

반응식

[NH2:1][C:2]1[C:7]([C:8](O)=[O:9])=[C:6]([Cl:11])[CH:5]=[C:4]([Cl:12])[CH:3]=1.[NH2:13][C:14](N)=[O:15]>>[Cl:11][C:6]1[CH:5]=[C:4]([Cl:12])[CH:3]=[C:2]2[C:7]=1[C:8](=[O:9])[NH:13][C:14](=[O:15])[NH:1]2

참가 물질

반응물 2

HCID 1176Urea

HCID 2904984,6-Dichloroanthranilic acid

생성물 1

HCID 15088015,7-dichloroquinazoline-2,4(1H,3H)-dione

실험 절차

Prepared according to general method C from 6-amino-2,4-dichlorobenzoic acid (2.0 g) and urea (5.83 g). Yield 1.72 g (77%) of a solid. 1H-NMR (DMSO-δ6) δ (ppm) 11.39 (br s, 2H), 7.32 (d, J=2.0 Hz, 1H), 7.15 (d, J=2.0 Hz, 1H).

후처리

customPrepared

출처 및 근거

ORD 기록: ord-ad5cdd3a84b0472f8d5153edea63ef4d
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08530486B2

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