Urea → 5-(Trifluoromethyl)quinazoline-2,4(1H,3H)-dione

반응식

[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[C:3]=1[C:4](O)=[O:5].[NH2:15][C:16](N)=[O:17]>>[F:12][C:11]([F:14])([F:13])[C:7]1[CH:8]=[CH:9][CH:10]=[C:2]2[C:3]=1[C:4](=[O:5])[NH:15][C:16](=[O:17])[NH:1]2

참가 물질

반응물 2

HCID 1176Urea

HCID 27785082-Amino-6-(trifluoromethyl)benzoic acid

생성물 1

HCID 341761265-(Trifluoromethyl)quinazoline-2,4(1H,3H)-dione

실험 절차

Prepared according to general method C from 2-amino-6-trifluoromethylbenzoic acid (1.0 g) and urea (2.92 g). Yield: 948 mg (85%) of a solid. 1H-NMR (DMSO-δ6) δ (ppm) 11.43 (br s, 2H), 7.78 (t, J=7.9 Hz, 1H), 7.58 (d, J=7.4 Hz, 1H), 7.48 (d, J=8.2 Hz, 1H).

후처리

customPrepared

출처 및 근거

ORD 기록: ord-85c7ce1600c24c7a972f69a53beef6cc
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08530486B2

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