Urea → 6-Bromo-7-chloroquinazoline-2,4-diol

HRID 40769

반응식

[NH2:1][C:2]1[CH:10]=[C:9]([Cl:11])[C:8]([Br:12])=[CH:7][C:3]=1[C:4](O)=[O:5].[NH2:13][C:14](N)=[O:15]>>[Br:12][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][C:9]=1[Cl:11])[NH:1][C:14](=[O:15])[NH:13][C:4]2=[O:5]

참가 물질

반응물 2

HCID 1176Urea

HCID 196120502-Amino-5-bromo-4-chlorobenzoic acid

생성물 1

HCID 196043396-Bromo-7-chloroquinazoline-2,4-diol

실험 절차

Prepared according to general method C from 2-amino-5-bromo-4-chlorobenzoic acid (987 mg) and urea (2.36 g). Yield: 1.00 g (92%) of a solid. 1H-NMR (DMSO-δ6) δ (ppm) 8.01 (s, 1H), 7.36 (s, 1H).

후처리

customPrepared

출처 및 근거

ORD 기록: ord-668748cef67a4c65b25c6ab24574f68c
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08530486B2

연결된 노트

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