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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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3-Bromofuran → (1RS, 2RS,6SR,7SR)-8-bromo-4-(2,4,6-trimethylphenyl)-10-oxatricyclo-[5.2.1.02,6]dec-8-en-3,5-dione

HRID 407856
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HRID 407856 반응식
[Br:1][C:2]1[CH:6]=[CH:5][O:4][CH:3]=1.[I-].[Mg+2].[I-].[CH3:10][C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[C:12]=1[CH:19]1[C:23](=[O:24])[CH:22]=[CH:21][C:20]1=[O:25]>ClCCl>[Br:1][C:2]1[CH:3]2[O:4][CH:5]([CH:6]=1)[CH:21]1[CH:22]2[C:23](=[O:24])[CH:19]([C:12]2[C:11]([CH3:10])=[CH:16][C:15]([CH3:17])=[CH:14][C:13]=2[CH3:18])[C:20]1=[O:25]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 891643-BromofuranHCID 5462737Magnesium diiodideHCID 666844242-(2,4,6-Trimethylphenyl)cyclopent-4-ene-1,3-dione

생성물 1

HCID 67284125(1RS, 2RS,6SR,7SR)-8-bromo-4-(2,4,6-trimethylphenyl)-10-oxatricyclo-[5.2.1.02,6]dec-8-en-3,5-dione

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3-Bromofuran (5.2 g, 56 mmol) and magnesium iodide (1.5 g, 5.6 mmol) are added to 2-(2,4,6-trimethylphenyl)cyclopent-4-ene-1,3-dione (4.0 g, 18.7 mmol) and the mixture is stirred at room temperature for 2 days; small quantities of dichloromethane are added when required to aid stirring. The reaction mixture is allowed to stand at room temperature for 17 hours, then concentrated under reduced pressure. The residue is purified by column chromatography on silica gel to give (1RS, 2RS,6SR,7SR)-8-bromo-4-(2,4,6-trimethylphenyl)-10-oxatricyclo-[5.2.1.02,6]dec-8-en-3,5-dione.

후처리

  1. stirringto aid stirring
  2. waitto stand at room temperature for 17 hours
  3. concentrationconcentrated under reduced pressure
  4. customThe residue is purified by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-3f6249c8f1ef4ca0ad83b3146435265c
출처 데이터셋
uspto-grants-2014_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08754242B2

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