Selenium Dioxide → 7-Bromo-2-quinolinecarboxaldehyde

HRID 408104노트

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HRID 408104 반응식
[Se](=O)=[O:2].[Br:4][C:5]1[CH:14]=[C:13]2[C:8]([CH:9]=[CH:10][C:11]([CH3:15])=[N:12]2)=[CH:7][CH:6]=1>O1CCOCC1>[Br:4][C:5]1[CH:14]=[C:13]2[C:8]([CH:9]=[CH:10][C:11]([CH:15]=[O:2])=[N:12]2)=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 24007Selenium DioxideHCID 123328967-Bromo-2-methylquinoline

생성물 1

HCID 366880237-Bromo-2-quinolinecarboxaldehyde수율 124.8%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

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온도
60 °C

실험 절차

Selenium dioxide (1.6 g, 14 mmol, 1.3 eq) was suspended in dioxan (50 mL) and was heated to 60° C. At this temperature 7-bromoquinaldine (2.5 g, 11.2 mmol) was introduced and the mixture was left at 80° C. for 3 hours. After cooling the mixture to room temperature, the crude slurry was filtered on celite, eluted with dioxan and concentrated under reduced pressure. The product was obtained pure as a brown solid (3.3 g, >98%) that was used without furter purification.

후처리

  1. temperatureAfter cooling the mixture to room temperature
  2. filtrationthe crude slurry was filtered on celite
  3. washeluted with dioxan
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e538b56964c2423a85a9c806175abb70
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759331B2

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