Acetic Acid → 2-Amino-3-chlorobenzene-1-thiol

HRID 408114

반응식

HRID 408114 반응식
[Cl:1][C:2]1[C:7]2[N:8]=C(N)[S:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.[OH-].[K+].CC(O)=O>O>[NH2:8][C:7]1[C:2]([Cl:1])=[CH:3][CH:4]=[CH:5][C:6]=1[SH:10]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 14797Potassium HydroxideHCID 298722-Benzothiazolamine, 4-chloro-

생성물 1

HCID 126786672-Amino-3-chlorobenzene-1-thiol

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
150 °C

실험 절차

The 4-chlorobenzo[d]thiazol-2-amine (2.00 g, 10.83 mmol) was combined with KOH (10.0 g, 178.2 mmol) and H2O (20 mL). The rsulting mixture was heated at 150° C. overnight. The solid became a thick paste overnight. After 24 h, the mixture was allowed to cool to room temperatureand diluted with H2O. A solution of AcOH was added to bring the pH down to 4 to 5.

후처리

  1. waitAfter 24 h
  2. temperatureto cool to room temperatureand

출처 및 근거

ORD 기록
ord-2ad08017ae52484e95441de1104e06c1
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759336B2

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