Nitric Acid → 5-chloro-4-fluoro-3-nitro-1H-pyrrolo[2,3-b]pyridine

반응식

[Cl:1][C:2]1[C:3]([F:11])=[C:4]2[CH:10]=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.[N+:12]([O-])([OH:14])=[O:13]>>[Cl:1][C:2]1[C:3]([F:11])=[C:4]2[C:10]([N+:12]([O-:14])=[O:13])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1

참가 물질

반응물 2

HCID 944Nitric Acid

HCID 534129535-Chloro-4-fluoro-1H-pyrrolo[2,3-B]pyridine

생성물 1

HCID 602052745-chloro-4-fluoro-3-nitro-1H-pyrrolo[2,3-b]pyridine수율 86%

실험 절차

5-Chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridine (1.2 g, 7.0 mmol) was added slowly to fuming nitric acid (10 mL) at 0° C. Upon completion of the addition, the reaction was stirred for 10 minutes, and then quenched with ice. Water was added until a precipitate formed, which was filtered, washed with water and dried to give the product 5-chloro-4-fluoro-3-nitro-1H-pyrrolo[2,3-b]pyridine (1.3 g, 86% yield).

후처리

additionUpon completion of the addition
customquenched with ice
additionWater was added until a precipitate
customformed
filtrationwhich was filtered
washwashed with water
customdried

출처 및 근거

ORD 기록: ord-bb7b386c954b4eea81d5a1ff849f80f5
출처 데이터셋: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08758830B2

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