Ethanol → Ethyl 3-nitropropionic acid

HRID 408446노트

반응식

HRID 408446 반응식
[N+:1]([CH2:4][CH2:5][C:6]([OH:8])=[O:7])([O-:3])=[O:2].S(=O)(=O)(O)O.[CH2:14](O)[CH3:15]>>[CH2:14]([CH:5]([CH2:4][N+:1]([O-:3])=[O:2])[C:6]([OH:8])=[O:7])[CH3:15]

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 16783-Nitropropionic acid

생성물 1

HCID 86703358Ethyl 3-nitropropionic acid

실험 절차

To a solution of 2 gr of 3-nitropropionic acid (41) in 30 mL of ethanol add catalytic amount of concentrated sulphuric acid (0.8 mL) and reflux overnight. Then add water and extracted with ethylacetate. The organic layer was washed with saturated sodium bicarbonate solution, saturated sodium chloride and water. Purification from column gives ethyl 3-nitropropionic acid (26) as pale yellow liquid with boiling point 92° C. at 2.5 torr.

후처리

  1. temperaturereflux overnight
  2. extractionThen add water and extracted with ethylacetate
  3. washThe organic layer was washed with saturated sodium bicarbonate solution, saturated sodium chloride and water
  4. customPurification from column

출처 및 근거

ORD 기록
ord-5550a87ede2a43dfb5d94e8070cc45ac
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759339B2

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