Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Chloride → 2-(2-Methoxyphenyl)acetaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Chloride | HCID 5234 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Sulfur trioxide | HCID 24682 | — |
| 반응물 | 2-Methoxyphenethyl alcohol | HCID 81909 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-(2-Methoxyphenyl)acetaldehyde | HCID 269548 | 86% |
반응 단계
A solution of pyridine complex with sulfur trioxide (134 g, 0.842 mol) in dimethylsulfoxide (150 mL) was slowly added to a solution of 2-(2-methoxy-phenyl)-ethanol (43 g, 0.28 mol) and triethylamine (86 g, 0.85 mol) in dichloromethane (500 mL) at 0° C. After being stirred 30 min, the mixture was poured into a saturated aqueous solution of sodium chloride and the organic layer was washed with dilute hydrochloric acid, a saturated aqueous solution of sodium chloride, dried over sodium sulfate and evaporated to dryness to give (2-methoxy-phenyl)-acetaldehyde (36 g, 0.24 mol, 86%) which was used in the next step directly.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08759335B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-74a84c87c09243949b11f5548591bc27 |
| 출처 메모 | uspto-grants-2014_06 |