Methyl 4-ethynyl-3-hydroxybenzoate → Methyl 6-benzofurancarboxylate
반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[C:12]#[CH:13])[C:5]([O:7][CH3:8])=[O:6]>C1(C)C=CC=CC=1>[O:1]1[C:2]2[CH:3]=[C:4]([C:5]([O:7][CH3:8])=[O:6])[CH:9]=[CH:10][C:11]=2[CH:12]=[CH:13]1참가 물질
3
반응 조건
- 온도
- 80 °C
실험 절차
To a solution of methyl 3-hydroxy-4-ethynylbenzoate (1 eq.) in dry toluene was added PtCl2 (0.1 eq.) under argon. The reaction mixture was stirred at 80° C. for 1.5 h, warmed to 20° C. and the solvents removed under reduced pressure. The crude was purified by chromatography on silica gel (elution with heptane/EtOAc: 9/1) to afford methyl benzofuran-6-carboxylate.
후처리
- temperaturewarmed to 20° C.
- customthe solvents removed under reduced pressure
- customThe crude was purified by chromatography on silica gel (elution with heptane/EtOAc: 9/1)
출처 및 근거
- ORD 기록
- ord-c9eb168d6fe1476c8eccc162875c299d
- 출처 데이터셋
- uspto-grants-2014_06
- 특허 번호
- US08759334B2
반응 노트
불러오는 중…