Methanol → Methyl azetidine-2-carboxylate hydrochloride

HRID 408610노트

반응식

HRID 408610 반응식
[NH:1]1[CH2:4][CH2:3][CH:2]1[C:5]([OH:7])=[O:6].S(Cl)([Cl:10])=O.[CH3:12]O>>[ClH:10].[CH3:12][O:6][C:5]([CH:2]1[CH2:3][CH2:4][NH:1]1)=[O:7]

참가 물질

4

반응물 3

HCID 887MethanolHCID 17288Azetidinecarboxylic AcidHCID 24386Thionyl Chloride

생성물 1

HCID 22476057Methyl azetidine-2-carboxylate hydrochloride

반응 조건

온도
20 °C

실험 절차

To a solution of azetidine-2-carboxylic acid (1 eq.) in MeOH at 0° C. was added dropwise thionyl chloride (2.5 eq.). The reaction was stirred at 20° C. for 15 h. The crude was concentrated under reduced pressure and used as such without further purification.

후처리

  1. concentrationThe crude was concentrated under reduced pressure
  2. customsuch without further purification

출처 및 근거

ORD 기록
ord-7e083845b2e44d96834f03e73cf5b337
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759334B2

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