Water → 5-Methylsulfanyl-2-nitro-4-trifluoromethyl-phenylamine

HRID 408722노트

반응식

HRID 408722 반응식
Cl[C:2]1[C:3]([C:12]([F:15])([F:14])[F:13])=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH2:8])[CH:7]=1.CN(C=O)C.[CH3:21][S-:22].[Na+].O>[Cl-].[Na+].O>[CH3:21][S:22][C:2]1[C:3]([C:12]([F:15])([F:14])[F:13])=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH2:8])[CH:7]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 6228DimethylformamideHCID 27738135-Chloro-2-nitro-4-(trifluoromethyl)anilineHCID 4378561Sodium methanethiolate

생성물 1

HCID 669372705-Methylsulfanyl-2-nitro-4-trifluoromethyl-phenylamine수율 95.3%

시약·촉매·용매 1

HCID 57417360Sodium chloride; water용매

반응 조건

온도
90 °C

실험 절차

To a solution of 5-chloro-2-nitro-4-trifluoromethyl-phenylamine (2.02 g, 8.40 mmol) and DMF (40 mL) was added sodium thiomethoxide (0.618 g, 8.82 mmol). The mixture was heated to 90° C. for 50 min, then poured into brine. Water was added to bring the total volume to 300 mL and the orange precipitate was collected to yield the titled compound (2.02 g, 95%). 1H NMR (400 MHz, CDCl3): 8.42 (s, 1H), 6.51 (s, 1H), 6.39 (br s, 2H), 2.53 (s, 3H).

후처리

  1. customthe orange precipitate was collected

출처 및 근거

ORD 기록
ord-afe3a7d3daca4331a1d6e08d0ada70f2
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759345B2

반응 노트

불러오는 중…