Ammonia → 5-Bromo-4-fluoro-2-nitroaniline

HRID 408736

반응식

HRID 408736 반응식
[Br:1][C:2]1[CH:7]=[C:6](F)[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][C:3]=1[F:12].[NH3:13]>CO>[Br:1][C:2]1[C:3]([F:12])=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH2:13])[CH:7]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 27362864-Bromo-2,5-difluoronitrobenzene

생성물 1

HCID 669372515-Bromo-4-fluoro-2-nitroaniline

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
60 °C

실험 절차

A mixture of 1-bromo-2,5-difluoro-4-nitro-benzene (1.50 g, 6.30 mmol) and 7M ammonia in methanol (25 mL) was heated in a sealed tube at 60° C. for 15 h. The reaction mixture was transferred to a round bottom flask, washing the sealed tube with EtOAc. The reaction mixture was concentrated, and the crude material was used in the next step without further purification.

후처리

  1. customThe reaction mixture was transferred to a round bottom flask
  2. washwashing the sealed tube with EtOAc
  3. concentrationThe reaction mixture was concentrated
  4. customthe crude material was used in the next step without further purification

출처 및 근거

ORD 기록
ord-58306cd599c14be59297b4ae57f9a0c7
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759345B2

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