Methanol → HCID 24744032, 화합물

HRID 408836

반응식

HRID 408836 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16](=[O:17])[C:15]3[N:14]=[CH:13][N:12]([CH3:18])[C:11]=3[N:10]=[C:9]2Cl)=[CH:4][CH:3]=1.[F:20][C:21]1[C:26]([F:27])=[C:25]([F:28])[CH:24]=[CH:23][C:22]=1[OH:29].CO>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16](=[O:17])[C:15]3[N:14]=[CH:13][N:12]([CH3:18])[C:11]=3[N:10]=[C:9]2[O:29][C:22]2[CH:23]=[CH:24][C:25]([F:28])=[C:26]([F:27])[C:21]=2[F:20])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 1231742,3,4-TrifluorophenolHCID 57614152HCID 57614152, 화합물

생성물 1

HCID 24744032HCID 24744032, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
140 °C

실험 절차

1-(4-Bromophenyl)-2-chloro-9-methyl-1,9-dihydro-6H-purin-6-one (150 mg, 0.4417 mmol) and 2,3,4-trifluorophenol (130.8 mg, 0.8834 mmol) are added to a vial, and the sealed mixture is heated with stirring at 140° C. for 23 h. Silica gel column chromatography (MeOH:CH2Cl2=0.5:99.5) gives the title compound as a white solid. 1H NMR (400 MHz, CDCl3) 7.66 (3H, m), 7.24 (2H, m), 7.00 (2H, m), 3.58 (3H, s). MS (M+1): 451.08; RT=1.31 min. The IC50 determined as described in Example 6 is 100 nanomolar or less.

후처리

  1. temperatureis heated

출처 및 근거

ORD 기록
ord-dd9828272f7349498ffe3bde326c78ab
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759361B2

연결된 노트

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