Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (2S)-methyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)-2-phenylacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 1-Dichlorophosphoryloxynaphthalene | HCID 575631 | — |
| 반응물 | Methyl phenylglycinate, L- | HCID 1201451 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (2S)-methyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)-2-phenylacetate | HCID 66779381 | — |
반응 단계
Using the general procedure for synthesizing naphthyl (aminoacid ester) phosphorochloridates, the HCl salt of (S)-methyl 2-amino-2-phenylacetate (2 g), naphthalen-1-yl phosphorodichloridate (2.59 g), TEA (2.76 mL) and DCM (60 mL) were combined to give (2S)-methyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)-2-phenylacetate as a pale yellow thick oil. The crude compound was taken forward without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08759318B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-1263948a19004717ad6165216af6756f |
| 출처 메모 | uspto-grants-2014_06 |