Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triacetoxyperiodinane → (1-Formylcyclopropyl)carbamic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triacetoxyperiodinane | HCID 159087 | — |
| 반응물 | tert-butyl N-(1-(hydroxymethyl)cyclopropyl)carbamate | HCID 11286907 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (1-Formylcyclopropyl)carbamic acid tert-butyl ester | HCID 10352385 | 87% |
반응 단계
To a solution of tert-butyl (1-(hydroxymethyl)cyclopropyl)carbamate (Bioorg. Med. Chem. Lett., 2008, 18(6), 2188) (135 mg, 0.72 mmoles) in DCM (8 mL) was added Dess-Martin periodinane (277 mg, 0.65 mmole). After stirring 1 hr, the reaction was filtered through celite and concentrated to a yellow oil which was further purified by Isolera (7%-70% ethyl acetate/hexanes) to provide 84 mg (87%) of tert-butyl (1-formylcyclopropyl)-carbamate as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08759358B1 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-6a8cbcfd92364f9db8d0711fef89a97d |
| 출처 메모 | uspto-grants-2014_06 |