Guaiacol → 4-Hydroxy-8-(2-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester

HRID 409239노트

반응식

HRID 409239 반응식
[CH3:1][O:2][C:3]([C:5]1[N:6]=[CH:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[CH:10][C:9]=2I)=[O:4].[CH3:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[OH:25]>>[CH3:1][O:2][C:3]([C:5]1[N:6]=[CH:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[CH:10][C:9]=2[O:25][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[O:18][CH3:17])=[O:4]

참가 물질

3

반응물 2

HCID 460GuaiacolHCID 67110147Methyl 4-hydroxy-8-iodoisoquinoline-3-carboxylate

생성물 1

HCID 671101324-Hydroxy-8-(2-methoxy-phenoxy)-isoquinoline-3-carboxylic acid methyl ester

실험 절차

The title compound was synthesized from 4-hydroxy-8-iodo-isoquinoline-3-carboxylic acid methyl ester and 2-methoxy-phenol in analogy to example 19d; MS-(+)-ion: M+1=326.4.

출처 및 근거

ORD 기록
ord-f1af8d47205a4763bca768fdef3eac4f
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759373B2

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