Dimethylamine → (5-Methoxy-benzooxazol-2-yl)-dimethyl-amine

HRID 409299노트

반응식

HRID 409299 반응식
Cl[C:2]1[O:3][C:4]2[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:5]=2[N:6]=1.[CH3:13][NH:14][CH3:15]>O>[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:4]2[O:3][C:2]([N:14]([CH3:15])[CH3:13])=[N:6][C:5]=2[CH:7]=1

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 118197122-Chloro-5-methoxy-1,3-benzoxazole

생성물 1

HCID 57344577(5-Methoxy-benzooxazol-2-yl)-dimethyl-amine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 2-chloro-5-methoxy-benzooxazole (1.52 g, 8.31 mmol) and a 40% solution of dimethylamine in water (15 mL) was refluxed for two hours before it was cooled to room temperature and partitioned between ethyl acetate and water. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo to give the title compound as a black oil (1.14 g): MS: (+) m/z 397.19 (M+1)

후처리

  1. custompartitioned between ethyl acetate and water
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-9a0395e96f20453fa9e17fceee467a63
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759373B2

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