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Beta-Alanine → (E)-2-(4-((5-(3,4-dichlorophenyl)furan-2-yl)methylene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid

HRID 409357
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HRID 409357 반응식
[O:1]=[C:2]1[N:6]([CH:7]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]([OH:10])=[O:9])[C:5](=[S:18])[NH:4][CH2:3]1.[Cl:19][C:20]1[CH:21]=[C:22]([C:27]2S[C:30]([CH:32]=O)=[CH:29][CH:28]=2)[CH:23]=[CH:24][C:25]=1[Cl:26].NCCC(O)=[O:38].CO.C(Cl)Cl>C(O)(=O)C>[Cl:19][C:20]1[CH:21]=[C:22]([C:27]2[O:38][C:30](/[CH:32]=[C:3]3/[NH:4][C:5](=[S:18])[N:6]([CH:7]([CH2:11][C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=4)[C:8]([OH:10])=[O:9])[C:2]/3=[O:1])=[CH:29][CH:28]=2)[CH:23]=[CH:24][C:25]=1[Cl:26]
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HCID 239Beta-AlanineHCID 167688395-(3,4-Dichlorophenyl)thiophene-2-carbaldehydeHCID 21226129Dichloromethane methanolHCID 57994057HCID 57994057, 화합물

생성물 1

HCID 57994048(E)-2-(4-((5-(3,4-dichlorophenyl)furan-2-yl)methylene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid

시약·촉매·용매 1

HCID 176
Acetic Acid
용매

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온도
80 °C

실험 절차

To a mixture of 2-(5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid (0.110g, 0.416 mmol) and 5-(3,4-dichloro-phenyl)thiophene-2-carbaldehyde (0.100 g, 0.416 mmol) in acetic acid 10 mL is added β-alanine (1.8 mg, 0.021 mmol) and heat to 80° C. for 16 h. The resulting reaction mixture is cooled down and the solvent is removed. The pure product (0.070 g, 0.144 mmol, red solid) is obtained by column chromatography using MeOH/DCM, 2-7% ration solvent system. The product is further purified by recryatallization in hexane and DCM mixture and got pure E-isomer. 1H-NMR (CDCl3/CD3OD/300 MHz): 7.84 (d, J=2.1 Hz, 1H), 7.60 (dd, J=8.7, 2.4 Hz, 1H), 7.44 (d, J=2.7 Hz, 1H), 7.17 (m, 6H), 6.85 (m, 1H), 6.42 (s, 1H), 5.61 (dd, J=11.1, 5.4 Hz, 1H), 3.66 (dd, J=14.1, 12.6 Hz, 1H), 3.53 (dd, J=14.1, 5.1 Hz, 1H). MS (ES−, m/z): 585.3 (M−, 100.0).

후처리

  1. customThe resulting reaction mixture
  2. temperatureis cooled down
  3. customthe solvent is removed
  4. customThe pure product (0.070 g, 0.144 mmol, red solid) is obtained by column chromatography
  5. customThe product is further purified by recryatallization in hexane

출처 및 근거

ORD 기록
ord-6aa79c135c52472b85f5ea4333c37c3d
출처 데이터셋
uspto-grants-2014_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08759384B2

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