Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 409410생성일: 2026년 10월 25일
1H-Isoindole-1,3(2H)-dione, 2-(bromomethyl)- → Methyl 3-(1,3-dioxoisoindolin-2-yl)-2-(thiophen-3-yl)propanoate
https://huagongshe.com/reaction/409410
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1H-Isoindole-1,3(2H)-dione, 2-(bromomethyl)- | HCID 79244 | — |
| 반응물 | Methyl 3-thienylacetate | HCID 94041 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Methyl 3-(1,3-dioxoisoindolin-2-yl)-2-(thiophen-3-yl)propanoate | HCID 59161752 | — |
반응 단계
To pure methyl 2-(thiophen-3-yl)acetate (E41) in THF cooled to −78° C. was added LiHMDS, and the solution stirred at −78° C. for 30 min. Then N-(bromomethyl)phthalimide was added directly, and the solution was allowed to warm to 0° C. The mixture was poured into NaHCO3 (sat), extracted with EtOAc, dried (Na2SO4), filtered, and evaporated. Column chromatography (SiO2, 0-40% EtOAc/Hex) gave pure methyl 3-(1,3-dioxoisoindolin-2-yl)-2-(thiophen-3-yl)propanoate (E45).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08759388B2 |
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| 출처 데이터셋 | uspto-grants-2014_06 |
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| ORD ID | ord-847c117ac2cf462db8991a06fd4e7cb6 |
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| 출처 메모 | uspto-grants-2014_06 |
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