Potassium Hydroxide → HCID 18317887, 화합물

HRID 409489노트

반응식

HRID 409489 반응식
[CH3:1][O:2][C:3]([C:5]1([C:10]([O:12]C)=[O:11])[CH2:9][CH2:8][CH2:7][CH2:6]1)=[O:4].[OH-].[K+]>CO>[CH3:1][O:2][C:3]([C:5]1([C:10]([OH:12])=[O:11])[CH2:9][CH2:8][CH2:7][CH2:6]1)=[O:4]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 12609605Dimethyl cyclopentane-1,1-dicarboxylate

생성물 1

HCID 18317887HCID 18317887, 화합물수율 100.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of cyclopentane-1,1-dicarboxylic acid dimethyl ester (4.0 g, 21.5 mmol) in MeOH (25 mL) is added potassium hydroxide (1.32 g, 23.7 mmol). The mixture is stirred at room temperature for 15 hours and concentrated under reduced pressure. To the obtained residue, aqueous 1M HCl (50 mL) is added and the solution is extracted with EtOAc. The organic layer is washed with H2O, dried over Na2SO4, and concentrated under reduced pressure to give cyclopentane-1,1-dicarboxylic acid methyl ester (3.72 g, quant.); TLC (dichloromethane/MeOH, 10:1) Rf 0.25.

후처리

  1. concentrationconcentrated under reduced pressure
  2. additionTo the obtained residue, aqueous 1M HCl (50 mL) is added
  3. extractionthe solution is extracted with EtOAc
  4. washThe organic layer is washed with H2O
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-50936aa06d8045f590105a42f7386f23
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759365B2

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