Methanol → HCID 178501210, 화합물

반응식

[NH2:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([C:8]([OH:10])=[O:9])[CH2:4][CH2:3]1.S(Cl)([Cl:13])=O.[CH3:15]O>>[ClH:13].[CH3:15][O:9][C:8]([C@H:5]1[CH2:6][CH2:7][C@H:2]([NH2:1])[CH2:3][CH2:4]1)=[O:10]

참가 물질

반응물 3

HCID 887Methanol

HCID 24386Thionyl Chloride

HCID 178511567HCID 178511567, 화합물

생성물 1

HCID 178501210HCID 178501210, 화합물수율 90%

실험 절차

To a solution of trans-4-aminocyclohexanecarboxylic acid (20 mmol, 2.86 g) in methanol (20 mL) is added thionyl chloride (24 mmol, 1.76 mL) at 0° C. The mixture is stirred at room temperature for 12 hours then concentrated under reduced pressure. The residue is washed with hexane to obtain 3.5 g (90%) of trans-4-aminocyclohexanecarboxylic acid methyl ester hydrochloride as white solid. ESI-MS m/z: 157 [M+1]+, Retention time 0.77 min (condition B).