Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,5-Bis(difluoromethyl)-1H-pyrazole-1-acetic acid → 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}-benzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,5-Bis(difluoromethyl)-1H-pyrazole-1-acetic acid | HCID 1229844 | — |
| 반응물 | HCID 178519461 | HCID 178519461 | — |
| 생성물 | 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}-benzaldehyde | HCID 86657566 | — |
반응 단계
4-{4-[5-(2-Formylphenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidinium chloride (433 mg) and [3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid (285 mg) were reacted analogously to I-40 (step 3). This gave 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-O-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}benzaldehyde (330 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08759527B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-6d927205360743d0a103329fc7a23125 |
| 출처 메모 | uspto-grants-2014_06 |