반응식
[O:1]1CCCO[CH:2]1[C:7]1[CH:8]=[CH:9][C:10]([C:13]2[S:21][C:20]3[C:15](=[N:16][CH:17]=[CH:18][C:19]=3[O:22][C:23]3[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][C:24]=3[F:32])[CH:14]=2)=[N:11][CH:12]=1>C(O)(=O)C.O>[F:32][C:24]1[CH:25]=[C:26]([N+:29]([O-:31])=[O:30])[CH:27]=[CH:28][C:23]=1[O:22][C:19]1[CH:18]=[CH:17][N:16]=[C:15]2[CH:14]=[C:13]([C:10]3[CH:9]=[CH:8][C:7]([CH:2]=[O:1])=[CH:12][N:11]=3)[S:21][C:20]=12참가 물질
4
반응 조건
- 온도
- 90 °C
실험 절차
A suspension of 318 (2.64 g, 5.82 mmol) in 80% aqueous acetic acid (42 mL) was heated at 90° C. for 18 h. The reaction mixture was cooled to r.t. and diluted with water. The resulting precipitate was collected by suction filtration. The solid was transferred to a round-bottomed flask, the remaining water was removed by azeotropic distillation with toluene (4 times), and the solid dried in vacuo yielding 325 (1.76 g, 76%). LRMS (M+H): 396.3
후처리
- temperatureThe reaction mixture was cooled to r.t.
- filtrationThe resulting precipitate was collected by suction filtration
- customThe solid was transferred to a round-bottomed flask
- customthe remaining water was removed by azeotropic distillation with toluene (4 times)
- customthe solid dried in vacuo
출처 및 근거
- ORD 기록
- ord-418ed5ad9efa4e0e800a5b5baeacf93f
- 출처 데이터셋
- uspto-grants-2014_06
- 특허 번호
- US08759522B2
연결된 노트
불러오는 중…