4-Bromoaniline → N-(4-Bromophenyl)-2-(2,2-difluoroethoxy)-4-cyclopropylamino-5-amino-benzamide

HRID 410106노트

반응식

HRID 410106 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:28])[C:10]2[CH:15]=[C:14]([N+:16]([O-])=O)[C:13]([NH:19][CH:20]3[CH2:22][CH2:21]3)=[CH:12][C:11]=2[O:23][CH2:24][CH:25]([F:27])[F:26])=[CH:4][CH:3]=1.FC1C=C(F)C([N+]([O-])=O)=CC=1C(O)=O.C1(N)CC1.BrC1C=CC(N)=CC=1.FC(F)CO>[Ni].[H][H]>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:28])[C:10]2[CH:15]=[C:14]([NH2:16])[C:13]([NH:19][CH:20]3[CH2:21][CH2:22]3)=[CH:12][C:11]=2[O:23][CH2:24][CH:25]([F:27])[F:26])=[CH:6][CH:7]=1

참가 물질

7

반응물 5

HCID 78074-BromoanilineHCID 69828CyclopropylamineHCID 1361872,2-Difluoroethan-1-olHCID 27828222,4-Difluoro-5-nitrobenzoic acidHCID 86669633N-(4-bromophenyl)-2-(2,2-difluoroethoxy)-4-cyclopropylamino-5-nitro-benzamide

생성물 1

HCID 86669632N-(4-Bromophenyl)-2-(2,2-difluoroethoxy)-4-cyclopropylamino-5-amino-benzamide

시약·촉매·용매 1

HCID 178506447HCID 178506447, 화합물촉매

실험 절차

The subtitle compound is prepared from N-(4-bromophenyl)-2-(2,2-difluoroethoxy)-4-cyclopropylamino-5-nitro-benzamide (prepared from 2,4-difluoro-5-nitrobenzoic acid, cyclopropylamine, 4-bromoaniline and 2,2-difluoroethanol in analogy to the examples 1c, 6a, 1e) and RaNi/H2 in analogy to example 5c.

출처 및 근거

ORD 기록
ord-82de4134b99642ad9588ec0d3469cb1c
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759537B2

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