Acetic Acid → HCID 67250894, 화합물

HRID 410388

반응식

HRID 410388 반응식
Cl[C:2]1[N:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][N:3]=1.[Br:10][C:11]1[CH:12]=[C:13]([CH:15]=[C:16]([CH3:18])[CH:17]=1)[NH2:14].C(O)(=O)C>O1CCOCC1>[Br:10][C:11]1[CH:12]=[C:13]([NH:14][C:2]2[N:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][N:3]=2)[CH:15]=[C:16]([CH3:18])[CH:17]=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 5889352-Chloro-4-methoxypyrimidineHCID 30185263-Bromo-5-methylaniline

생성물 1

HCID 67250894HCID 67250894, 화합물수율 100%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
120 °C

실험 절차

A 10-20 mL microwave vial was charged with 2-chloro-4-methoxypyrimidine (0.835 g, 5.78 mmol), 3-bromo-5-methylaniline (1.075 g, 5.78 mmol), acetic acid (0.347 mL, 6.06 mmol) and dioxane (11.55 mL). The system was purged and flushed with Ar(g) three times before sealing and heating to 120° C. for 3 hours. The mixture was cooled and stirred overnight. The light brown solids were collected by filtration and were dried in a vacuum oven overnight to yield N-(3-bromo-5-methylphenyl)-4-methoxypyrimidin-2-amine (1.7 g, 5.78 mmol, 100% yield) as a tan solid. MS ESI: [M+H]+ m/z 296.0.

후처리

  1. customThe system was purged
  2. customflushed with Ar(g) three times
  3. temperatureThe mixture was cooled
  4. filtrationThe light brown solids were collected by filtration
  5. customwere dried in a vacuum oven overnight

출처 및 근거

ORD 기록
ord-842358daa5af4a84a723a68096a3efff
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759366B2

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