참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Iodoethane | HCID 6340 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 5-Hydroxyindole | HCID 16054 | — |
| 반응물 | Dichloromethane methanol | HCID 21226129 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 5-Ethoxy-1H-indole | HCID 4777667 | 90% |
반응 단계
A mixture of commercially available 5-hydroxy-indole (18 g, 13.5 mmol), anhydrous K2CO3 (93.5 g, 5 equiv) and iodoethane (40.5 ml, 3.75 equiv) in acetone (180 mL) is stirred at 50° C. under argon. When TLC (dichloromethane-methanol, 95:5) indicates the disappearance of 5-hydroxy-indole (4 days), the mixture is filtered, the solid is washed with acetone, then the filtrate is concentrated to give 17.67 g (90%) of the title compound, which is sufficiently pure to be used in the next step. M.p. 144-146° C. (from ethanol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08530493B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-7954df6899c24f36acc08db5c4700c76 |
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| 출처 메모 | uspto-grants-2013_09 |
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