Cesium carbonate → Methyl 4-{1-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]ethenyl}benzoate

HRID 410684

반응식

HRID 410684 반응식
Br[C:2]1[S:6][C:5]([C:7]([C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:11][CH:10]=2)=[CH2:8])=[N:4][CH:3]=1.[CH3:19][C:20]1[CH:21]=[C:22]([NH:35][C:36]2[N:41]=[C:40]([C:42]([F:45])([F:44])[F:43])[CH:39]=[CH:38][N:37]=2)[CH:23]=[C:24](B2OC(C)(C)C(C)(C)O2)[CH:25]=1.C(=O)([O-])[O-].[Cs+].[Cs+].CC(C1C=C(C(C)C)C(C2C=CC=CC=2P(C2CCCCC2)C2CCCCC2)=C(C(C)C)C=1)C>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[CH3:19][C:20]1[CH:25]=[C:24]([C:2]2[S:6][C:5]([C:7]([C:9]3[CH:18]=[CH:17][C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:11][CH:10]=3)=[CH2:8])=[N:4][CH:3]=2)[CH:23]=[C:22]([NH:35][C:36]2[N:41]=[C:40]([C:42]([F:45])([F:43])[F:44])[CH:39]=[CH:38][N:37]=2)[CH:21]=1

참가 물질

6

반응물 4

HCID 10796Cesium carbonateHCID 111557942-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenylHCID 58456089N-(3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4-(trifluoromethyl)pyrimidin-2-amine2회HCID 58456378Methyl 4-[1-(5-bromo-1,3-thiazol-2-yl)-ethenyl]benzoate2회

생성물 1

HCID 67257947Methyl 4-{1-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]ethenyl}benzoate수율 29.9%

시약·촉매·용매 1

HCID 9811564Bis(dibenzylideneacetone)palladium촉매

반응 조건

온도
60 °C

실험 절차

A microwave vial was charged with methyl 4-[1-(5-bromo-1,3-thiazol-2-yl)-ethenyl]benzoate (INTERMEDIATE 89, 0.225 g, 0.694 mmol), N-[3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine (INTERMEDIATE 3, 0.263 g, 0.694 mmol), Pd2(dba)3 (0.032 g, 0.035 mmol), cesium carbonate (0.452 g, 1.388 mmol) and X-Phos (0.033 g, 0.069 mmol). The vial was sealed and purged with Argon gas. Dioxane (2.43 mL) and water (0.24 mL) were added and the mixture was stirred at 60° C. for 75 minutes. The temperature was increased to 90° C. and reacted overnight. The resulting solution was cooled and filtered through a celite plug, washing with EtOAc and then concentrated. Chromatography on silica gel (Biotage 100G SNAP, 10-65% EtOAc/hexanes) afforded methyl 4-{1-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]ethenyl}benzoate (103 mg, 0.207 mmol, 29.9% yield). MS ESI: [M+H]+ m/z 497.0.

후처리

  1. customThe vial was sealed
  2. custompurged with Argon gas
  3. additionDioxane (2.43 mL) and water (0.24 mL) were added
  4. temperatureThe temperature was increased to 90° C.
  5. customreacted overnight
  6. temperatureThe resulting solution was cooled
  7. filtrationfiltered through a celite plug
  8. washwashing with EtOAc
  9. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5687aa59eac74197bfa5b0734eeb9795
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759366B2

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