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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 410727생성일: 2026년 10월 26일

2-Methoxyethylamine → 1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzo-imidazole-5-carboxylic acid (2-methoxy-ethyl)-amide

https://huagongshe.com/reaction/410727

반응식

참여 물질

역할이름HCID투입량
반응물2-MethoxyethylamineHCID 8018—
반응물DiisopropylethylamineHCID 81531—
반응물P,P-Diphenylphosphinic azideHCID 199401—
반응물1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acidHCID 58397517—
생성물1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzo-imidazole-5-carboxylic acid (2-methoxy-ethyl)-amideHCID 5741206919.7%

반응 단계

1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzo-imidazole-5-carboxylic acid (2-methoxy-ethyl)-amide (22 mg) was prepared by following General Procedure N starting from 1-methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid (100 mg), 2-methoxy-ethylamine (18 mg), DPPA (53 uL), and DIEA (43 uL). LC/MS: m/z 466.9. 1H NMR (DMSO-d6, 400 MHz): δ 12.36 (bs, 1H), 8.47 (s, 1H), 8.08 (s, 1H), 7.89 (s, 1H), 7.76 (s, 1H), 7.71 (d, 1H), 7.47 (d, 1H), 7.34 (d, 1H), 3.62 (bs, 3H), 3.53-3.38 (m, 4H), 3.27 (s, 3H).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08759535B2
출처 데이터셋uspto-grants-2014_06
ORD IDord-64568e67049345508a2494ebd7b8d425
출처 메모uspto-grants-2014_06