Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,1'-Thiocarbonyldiimidazole → 1-Methyl-2-(6-trifluoromethyl-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,1'-Thiocarbonyldiimidazole | HCID 80264 | — |
| 반응물 | 2-Amino-6-(trifluoromethyl)benzothiazole | HCID 2735955 | — |
| 반응물 | Methyl 3-amino-4-(methylamino)benzoate | HCID 15586064 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 생성물 | 1-Methyl-2-(6-trifluoromethyl-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid methyl ester | HCID 58397678 | 41.1% |
반응 단계
1-Methyl-2-(6-trifluoromethyl-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid methyl ester (765 mg) was prepared by following General Procedure D starting from 3-amino-4-methylamino-benzoic acid methyl ester (991 mg), 2-amino-6-(trifluoromethyl)benzothiazole (1.0 g), 1,1′-thiocarbonyldiimidazole (1.09 g), and EDC (1.32 g). LC/MS: m/z 407.9. 1H NMR (DMSO-d6, 400 MHz): δ 12.37 (bs, 1H), 8.15 (s, 1H), 7.97 (d, 1H), 7.95 (d, 1H), 7.85 (d, 1H), 7.62-7.43 (m, 2H), 3.86 (s, 3H), 3.62 (bs, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08759535B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-8794ca0dfbb84ec39ee64180237b0611 |
| 출처 메모 | uspto-grants-2014_06 |