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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 410743생성일: 2026년 10월 26일

Lithium Hydroxide → 1-Methyl-2-(6-trifluoromethyl-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid

https://huagongshe.com/reaction/410743

반응식

참여 물질

역할이름HCID투입량
반응물Lithium HydroxideHCID 3939—
반응물1-Methyl-2-(6-trifluoromethyl-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid methyl esterHCID 58397678—
생성물1-Methyl-2-(6-trifluoromethyl-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acidHCID 5839768558.8%

반응 단계

1-Methyl-2-(6-trifluoromethyl-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid (434 mg) was prepared by following General Procedure E starting from 1-methyl-2-(6-trifluoromethyl-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid methyl ester (765 mg) and lithium hydroxide (316 mg). LC/MS: m/z 393.9. 1H NMR (DMSO-d6, 400 MHz): δ 12.77 (bs, 1H), 12.49 (bs, 1H), 8.34-8.14 (m, 2H), 7.93-7.73 (m, 2H), 7.67 (d, 1H), 7.52 (d, 1H), 3.64 (bs, 3H).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08759535B2
출처 데이터셋uspto-grants-2014_06
ORD IDord-7aab9caaefb7426895236dfb1393d64a
출처 메모uspto-grants-2014_06