Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-Chloro-2-benzothiazolamine → 2-(6-Chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-Chloro-2-benzothiazolamine | HCID 7226 | — |
| 반응물 | 1,1'-Thiocarbonyldiimidazole | HCID 80264 | — |
| 반응물 | Methyl 3-amino-4-(methylamino)benzoate | HCID 15586064 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 생성물 | 2-(6-Chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid methyl ester | HCID 58397554 | 75% |
반응 단계
2-(6-Chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid methyl ester (842 mg) was prepared by following General Procedure D starting from 3-amino-4-methylamino-benzoic acid methyl ester (650 mg), 2-amino-6-chloro-benzothiazole (556 mg), 1,1′-thiocarbonyldiimidazole (715 mg), and EDC (865 mg). LC/MS: m/z 373.7. 1H NMR (DMSO-d6, 400 MHz): δ 12.39 (bs, 1H), 8.19 (s, 1H), 7.92 (s, 1H), 7.84 (s, 1H), 7.64 (s, 1H), 7.50 (d, 1H), 7.38 (d, 1H), 3.86 (s, 3H), 3.62 (bs, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08759535B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-43c9dbbd068d4211a01887a7c84e17f9 |
| 출처 메모 | uspto-grants-2014_06 |