HCID 59395139, 화합물 → HCID 67333436, 화합물

HRID 410766노트

반응식

HRID 410766 반응식
[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[C:7]([NH:13][CH3:14])=[CH:6][C:5]=1[F:15]>[Pd]>[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([NH2:10])[C:7]([NH:13][CH3:14])=[CH:6][C:5]=1[F:15]

참가 물질

3

반응물 1

HCID 59395139HCID 59395139, 화합물

생성물 1

HCID 67333436HCID 67333436, 화합물수율 88.3%

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

5-Amino-2-fluoro-4-methylamino-benzoic acid methyl ester (115 mg) was prepared by following General Procedure B starting from 2-fluoro-4-methylamino-5-nitro-benzoic acid methyl ester (150 mg) and Pd/C (10% by weight, 15 mg). The crude product was used in the next step without further purification.

후처리

  1. customThe crude product was used in the next step without further purification

출처 및 근거

ORD 기록
ord-bb4a58489da942f2b8b4ab9e3527896c
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759535B2

반응 노트

불러오는 중…