Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-6-methylbenzothiazole → 1-methyl-2-(6-methyl-benzothiazol-2-ylamino)-1H-benzimidazole-5-carboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-6-methylbenzothiazole | HCID 17335 | — |
| 반응물 | 1,1'-Thiocarbonyldiimidazole | HCID 80264 | — |
| 반응물 | Methyl 3-amino-4-(methylamino)benzoate | HCID 15586064 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 생성물 | 1-methyl-2-(6-methyl-benzothiazol-2-ylamino)-1H-benzimidazole-5-carboxylic acid methyl ester | HCID 58397627 | 83.5% |
반응 단계
1-Methyl-2-(6-methyl-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid methyl ester (1.47 g) was prepared by following General Procedure D starting from 3-amino-4-methylamino-benzoic acid methyl ester (0.9 g), 2-amino-6-methyl-benzothiazole (0.82 g), 1,1′-thiocarbonyldiimidazole (1.07 g), and EDC (1.15 g). LC/MS: m/z 354.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08759535B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-ea4992c285a04c8a86ae1c6ff5a5a075 |
| 출처 메모 | uspto-grants-2014_06 |