2-Methoxyethylamine → Methyl 4-((2-methoxyethyl)amino)-3-nitrobenzoate

HRID 410902노트

반응식

HRID 410902 반응식
Cl[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[CH3:15][O:16][CH2:17][CH2:18][NH2:19]>CN(C=O)C>[CH3:9][O:8][C:6](=[O:7])[C:5]1[CH:10]=[CH:11][C:2]([NH:19][CH2:18][CH2:17][O:16][CH3:15])=[C:3]([N+:12]([O-:14])=[O:13])[CH:4]=1

참가 물질

4

반응물 2

HCID 80182-MethoxyethylamineHCID 735797Methyl 4-chloro-3-nitrobenzoate

생성물 1

HCID 67335214Methyl 4-((2-methoxyethyl)amino)-3-nitrobenzoate수율 81.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

4-(2-Methoxy-ethylamino)-3-nitro-benzoic acid methyl ester (960.0 mg) was prepared by following General Procedure A starting from methyl 4-chloro-3-nitrobenzoate (1.0 g) and 2-methoxy-ethylamine (413.0 mg) in DMF (10.0 mL). The crude product was used in the next step without further purification.

후처리

  1. customThe crude product was used in the next step without further purification

출처 및 근거

ORD 기록
ord-2d6bd3c84a2c4c2eb409de875b20f45e
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759535B2

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