N-BOC-ethylenediamine → HCID 67332341, 화합물

HRID 410911노트

반응식

HRID 410911 반응식
Cl[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[C:15]([O:19][C:20](=[O:25])[NH:21][CH2:22][CH2:23][NH2:24])([CH3:18])([CH3:17])[CH3:16]>CN(C=O)C>[CH3:9][O:8][C:6](=[O:7])[C:5]1[CH:10]=[CH:11][C:2]([NH:24][CH2:23][CH2:22][NH:21][C:20]([O:19][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:25])=[C:3]([N+:12]([O-:14])=[O:13])[CH:4]=1

참가 물질

4

반응물 2

HCID 187201N-BOC-ethylenediamineHCID 735797Methyl 4-chloro-3-nitrobenzoate

생성물 1

HCID 67332341HCID 67332341, 화합물수율 76.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

4-(2-tert-Butoxycarbonylamino-ethylamino)-3-nitro-benzoic acid methyl ester (650.0 mg) was prepared by following General Procedure A starting from methyl 4-chloro-3-nitrobenzoate (542.0 mg) and (2-amino-ethyl)-carbamic acid tert-butyl ester (500.0 mg) in DMF (3.0 mL). The crude product was used in the next step without further purification.

후처리

  1. customThe crude product was used in the next step without further purification

출처 및 근거

ORD 기록
ord-454a9aafd45543a6a4351ff9f206f737
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759535B2

반응 노트

불러오는 중…