1,2-Dichloroethane → 2-(6-Chloro-benzothiazol-2-ylamino)-1-ethyl-1H-benzoimidazole-5-carboxylic acid methyl ester

HRID 410918

반응식

HRID 410918 반응식
[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][CH3:12])=[C:6]([NH2:13])[CH:5]=1.[NH2:15][C:16]1[S:17][C:18]2[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:19]=2[N:20]=1.[C:26](N1C=CN=C1)(N1C=CN=C1)=S.C(Cl)CCl>CN(C=O)C>[CH3:1][O:2][C:3]([C:4]1[CH:9]=[CH:8][C:7]2[N:10]([CH2:11][CH3:12])[C:26]([NH:15][C:16]3[S:17][C:18]4[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:19]=4[N:20]=3)=[N:13][C:6]=2[CH:5]=1)=[O:14]

참가 물질

6

반응물 4

HCID 111,2-DichloroethaneHCID 72266-Chloro-2-benzothiazolamineHCID 802641,1'-ThiocarbonyldiimidazoleHCID 12758354Methyl 3-amino-4-(ethylamino)benzoate

생성물 1

HCID 866568582-(6-Chloro-benzothiazol-2-ylamino)-1-ethyl-1H-benzoimidazole-5-carboxylic acid methyl ester수율 44.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2-(6-Chloro-benzothiazol-2-ylamino)-1-ethyl-1H-benzoimidazole-5-carboxylic acid methyl ester (926.0 mg) was prepared by following General Procedure D starting from 3-amino-4-ethylamino-benzoic acid methyl ester (1.06 g), 2-amino-6-chloro-benzothiazole (1.0 g), 1,1′-thiocarbonyldiimidazole (979.0 mg), and EDC (1.05 g) in DMF (5.0 mL).

출처 및 근거

ORD 기록
ord-e7ec5da136ff46938af3cf292432a0c8
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759535B2

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