Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-(2-Chloroethyl)dibenzylamine → [2-(2-Dibenzylamino-ethoxy)-ethyl]methyl-carbamic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-(2-Chloroethyl)dibenzylamine | HCID 5820 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | N-(tert-Butoxycarbonyl)-N-methyl-2-aminoethanol | HCID 545700 | — |
| 촉매 | Tetrabutylammonium Bromide | HCID 74236 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | [2-(2-Dibenzylamino-ethoxy)-ethyl]methyl-carbamic acid tert-butyl ester | HCID 67332450 | 32.6% |
반응 단계
[2-(2-Dibenzylamino-ethoxy)-ethyl]-methyl-carbamic acid tert-butyl ester (200 mg) was prepared by following General Procedure S starting from dibenzyl-(2-chloro-ethyl)-amine (400 mg), (2-hydroxy-ethyl)-methyl-carbamic acid tert-butyl ester (525 mg), 50% (w/w) KOH solution (1.8 mL) and tetrabutylammonium bromide (57.7 mg) in dioxane (1.8 mL).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08759535B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-843280e7221d4553b5e61ad4043f6770 |
| 출처 메모 | uspto-grants-2014_06 |