1,2-Dichloroethane → 2-(6-Chloro-benzothiazol-2-ylamino)-3-methyl-3H-benzoimidazole-5-carboxylic acid ethyl ester

HRID 411005

반응식

HRID 411005 반응식
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([NH2:9])[S:8][C:4]=2[CH:3]=1.[CH2:12]([O:14][C:15](=[O:25])[C:16]1[CH:21]=[CH:20][C:19]([NH2:22])=[C:18]([NH:23][CH3:24])[CH:17]=1)[CH3:13].[CH2:26](Cl)CCl>CN(C=O)C>[CH2:12]([O:14][C:15]([C:16]1[CH:21]=[CH:20][C:19]2[N:22]=[C:24]([NH:9][C:7]3[S:8][C:4]4[CH:3]=[C:2]([Cl:1])[CH:11]=[CH:10][C:5]=4[N:6]=3)[N:23]([CH3:26])[C:18]=2[CH:17]=1)=[O:25])[CH3:13]

참가 물질

5

반응물 3

HCID 111,2-DichloroethaneHCID 72266-Chloro-2-benzothiazolamineHCID 67332734Ethyl 4-amino-3-(methylamino)benzoate

생성물 1

HCID 866569172-(6-Chloro-benzothiazol-2-ylamino)-3-methyl-3H-benzoimidazole-5-carboxylic acid ethyl ester수율 50.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2-(6-Chloro-benzothiazol-2-ylamino)-3-methyl-3H-benzoimidazole-5-carboxylic acid ethyl ester (1.2 g) was prepared by following General Procedure D starting from 6-chloro-benzothiazol-2-ylamine (1.2 g), 4-amino-3-methylamino-benzoic acid ethyl ester (1.2 g), thioCDI (1 g) and EDC (1.1 g) in DMF (20 mL).

출처 및 근거

ORD 기록
ord-ba0f8b98fd95480487050731fa17760c
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759535B2

연결된 노트

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