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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 411055생성일: 2026년 10월 26일

1,2-Dichloroethane → 2-(6-Isopropyl-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid dimethylcarbamoylmethyl-amide

https://huagongshe.com/reaction/411055

반응식

참여 물질

역할이름HCID투입량
반응물1,2-DichloroethaneHCID 11—
반응물6-Isopropyl-benzothiazol-2-ylamineHCID 600983—
반응물3-Amino-N-dimethylcarbamoylmethyl-4-methylamino-benzamideHCID 67333499—
용매DimethylformamideHCID 6228—
생성물2-(6-Isopropyl-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid dimethylcarbamoylmethyl-amideHCID 866569713.4%

반응 단계

2-(6-Isopropyl-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid dimethylcarbamoylmethyl-amide (12 mg) was prepared by following General Procedure D starting from 6-isopropyl-benzothiazol-2-ylamine (150 mg), 3-amino-N-dimethylcarbamoylmethyl-4-methylamino-benzamide (200 mg), thioCDI (200 mg) and EDC (200 mg) in DMF (3 mL). LC/MS: m/z 450.6.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08759535B2
출처 데이터셋uspto-grants-2014_06
ORD IDord-3404170c53984897bfee0c1c0f9e2fd2
출처 메모uspto-grants-2014_06