HCID 20583266, 화합물 → HCID 85803722, 화합물

HRID 411219노트

반응식

HRID 411219 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N+:16]([O-])=O)=[C:6]([S:8]([CH2:11][C:12]([O:14][CH3:15])=[O:13])(=[O:10])=[O:9])[CH:7]=1.[H][H]>CO.[Pd]>[NH2:16][C:5]1[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][C:6]=1[S:8]([CH2:11][C:12]([O:14][CH3:15])=[O:13])(=[O:10])=[O:9]

참가 물질

5

반응물 2

HCID 20583266HCID 20583266, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 85803722HCID 85803722, 화합물수율 99%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Palladium (10%) on carbon is added to a solution of methyl ((5-methyl-2-nitro-phenyl)sulfonyl)acetate (Preparation 37, 2.0 g) in MeOH (60 mL) and the solution is shaken on a Parr apparatus under 30 psi of hydrogen. After 3 hours the solution is filtered through Celite and the filter cake eluted with MeOH (60 mL). The combined MeOH eluant is evaporated and the remaining residue placed under high vacuum overnight to obtain 1.76 g (99%) of the title compound as a dark solid. Physical characteristics: MS (ESI+) m/z 244 (M+H).

후처리

  1. filtrationAfter 3 hours the solution is filtered through Celite
  2. washthe filter cake eluted with MeOH (60 mL)
  3. customThe combined MeOH eluant is evaporated
  4. customplaced under high vacuum overnight

출처 및 근거

ORD 기록
ord-c37dd00edc08404685046128b31fa557
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06559145B2

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