Sodium Iodide → 2-Iodo-N-[3,4-bis(phenylmethoxy)phenyl]acetamide

HRID 4113

반응식

HRID 4113 반응식
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:8]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:7]=1)=[O:4].[I-:28].[Na+]>CC(C)=O>[I:28][CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:8]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:7]=1)=[O:4]

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 201534662-Chloro-N-[3,4-bis(phenylmethoxy)phenyl]acetamide

생성물 1

HCID 201534732-Iodo-N-[3,4-bis(phenylmethoxy)phenyl]acetamide수율 60.4%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A solution of 2-chloro-N-[3,4-bis(phenylmethoxy)phenyl]acetamide (8.98 g, 23.5 mmol) and sodium iodide (3.53 g, 23.5 mmol) in acetone (75 ml) was refluxed for two hours and allowed to stand overnight at room temperature. The reaction was filtered hot to remove the sodium iodide and a precipitate formed in the cold filtrate which was collected and washed with cold acetone to give, upon drying, 6.71 g (14.2 mmol) of the title compound. A second crop was obtained from cold acetone (1.0 g).

후처리

  1. filtrationThe reaction was filtered hot
  2. customto remove the sodium iodide
  3. customa precipitate formed in the cold filtrate which
  4. customwas collected
  5. washwashed with cold acetone
  6. customto give
  7. customupon drying

출처 및 근거

ORD 기록
ord-b6175eeac55148129b4ba8d24ceb3f10
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04723002

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