(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid → 4-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-4-phenyl-1,2,3,4-tetrahydroisoquinolin-3-one

HRID 411343노트

반응식

HRID 411343 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([OH:17])=O)[CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.[NH2:18][CH:19]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22](C2C=NC=CC=2)[NH:21][C:20]1=[O:35]>>[F:8][C:6]1[CH:5]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([NH:18][C:19]2([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:22][NH:21][C:20]2=[O:35])=[O:17])[CH3:14])=[O:11])[CH:3]=[C:2]([F:1])[CH:7]=1

참가 물질

3

반응물 2

HCID 12135350(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acidHCID 223127724-Amino-1-(pyrid-3-yl)-1,2,3,4-tetrahydroisoquinoline-3-one

생성물 1

HCID 205829494-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-4-phenyl-1,2,3,4-tetrahydroisoquinolin-3-one

실험 절차

Following General Procedure D above using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and 4-amino-6-phenyl-1,2,3,4-tetrahydroisoquinoline-3-one (General Procedure 5-D), the title compound was prepared. The product was purified by LC 2000 chromatography, eluting with ethyl acetate.

후처리

  1. customThe product was purified by LC 2000 chromatography
  2. washeluting with ethyl acetate

출처 및 근거

ORD 기록
ord-fc6d75b237034f57908c9732cf631003
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06559141B2

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