3,4-Dichloroaniline → N-(3,4-dichlorophenyl)alanine n-butyl Ester

HRID 411421

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[Cl:9])[NH2:5].[C:10]([O:15][CH2:16][CH2:17][CH2:18][CH3:19])(=[O:14])[C:11]([CH3:13])=O>>[CH2:16]([O:15][C:10](=[O:14])[C@H:11]([CH3:13])[NH:5][C:4]1[CH:6]=[CH:7][C:8]([Cl:9])=[C:2]([Cl:1])[CH:3]=1)[CH2:17][CH2:18][CH3:19]

참가 물질

반응물 2

HCID 72573,4-Dichloroaniline

HCID 523883Butyl pyruvate

생성물 1

HCID 53854721N-(3,4-dichlorophenyl)alanine n-butyl Ester

실험 절차

Following General Procedure AA above and using 3,4-dichloroaniline (Aldrich) and n-butyl pyruvate (prepared by following General Procedure AO above using n-butanol in place of iso-butanol), the title compound was prepared. The reaction was monitered by tlc on silica gel (Rf=0.7 in 25% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).

후처리

customThe reaction was monitered by tlc on silica gel (Rf=0.7 in 25% EtOAc/hexanes) and purification

출처 및 근거

ORD 기록: ord-53df398bc8604bfa99364e00eda8426d
출처 데이터셋: uspto-grants-2003_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06559141B2

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