methyl (1R,3S,4S)-3-methoxy-4-(nitrooxy)cyclopentanecarboxylate → (1RS,3RS,4SR)-3-methoxy-4-(nitrooxy)cyclopentanecarboxylic acid

HRID 41153노트

반응식

HRID 41153 반응식
[CH3:1][O:2][C@@H:3]1[C@@H:7]([O:8][N+:9]([O-:11])=[O:10])[CH2:6][C@H:5]([C:12]([O:14]C)=[O:13])[CH2:4]1.COC1C(O[N+]([O-])=O)CC(C(OC)=O)C1>>[CH3:1][O:2][CH:3]1[CH:7]([O:8][N+:9]([O-:11])=[O:10])[CH2:6][CH:5]([C:12]([OH:14])=[O:13])[CH2:4]1

참가 물질

3

반응물 2

HCID 66753156methyl (1R,3S,4S)-3-methoxy-4-(nitrooxy)cyclopentanecarboxylateHCID 67396922methyl (1RS,3RS,4RS)-3-methoxy-4-(nitrooxy)cyclopentanecarboxylate

생성물 1

HCID 46220317(1RS,3RS,4SR)-3-methoxy-4-(nitrooxy)cyclopentanecarboxylic acid

실험 절차

The title compound was prepared by following step D for example 1, except that the reagent (+)-methyl (1R,3S,4S)-3-methoxy-4-(nitrooxy)cyclopentanecarboxylate was replaced by methyl (1RS,3RS,4SR)-3-methoxy-4-(nitrooxy)cyclopentanecarboxylate. 1H NMR (500 MHz, CDCl3) δ 2.15-2.27 (m, 3H), 2.34-2.41 (m, 1H), 3.15-3.20 (m, 1H), 3.40 (s, 3H), 4.03 (m, 1H), 5.42 (m, 1H).

출처 및 근거

ORD 기록
ord-7a6938dcccf040349bac67c858a7d4ea
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530521B2

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