Ammonium Hydroxide → 4-{[(2R)-3-Amino-2-hydroxypropyl]oxy}benzonitrile

HRID 411540노트

반응식

HRID 411540 반응식
[O:1]1[CH2:3][C@@H:2]1[CH2:4][O:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1.[NH4+:14].[OH-]>C(O)(C)C>[NH2:14][CH2:3][C@@H:2]([OH:1])[CH2:4][O:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 6934186(R)-4-(Oxiran-2-ylmethoxy)benzonitrile

생성물 1

HCID 300720964-{[(2R)-3-Amino-2-hydroxypropyl]oxy}benzonitrile수율 91%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

4-[(2R)-Oxiranylmethoxy]benzonitrile (see step (i) above; 14.65 g, 83.6 mmol) was mixed with NH4OH (conc., 64 mL) and 87 mL of isopropanol. The mixture was stirred at rt for 18 h. The reaction mixture was then filtered and evaporated to give 14.6 g (91%) of the sub-title compound as a white solid.

후처리

  1. filtrationThe reaction mixture was then filtered
  2. customevaporated

출처 및 근거

ORD 기록
ord-dab5659829564b2dac29ccc1ae92c8e7
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06559162B2

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