Water → 2-(4-Acetyl-1-piperazinyl)ethyl 1H-imidazole-1-carboxylate

HRID 411555

반응식

HRID 411555 반응식
[C:1](N1C=CN=C1)([N:3]1[CH:7]=[CH:6][N:5]=[CH:4]1)=[O:2].[OH:13][CH2:14][CH2:15][N:16]1[CH2:21][CH2:20][N:19]([C:22](=[O:24])[CH3:23])[CH2:18][CH2:17]1.O>C(Cl)Cl>[N:3]1([C:1]([O:13][CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][N:19]([C:22](=[O:24])[CH3:23])[CH2:18][CH2:17]2)=[O:2])[CH:7]=[CH:6][N:5]=[CH:4]1

참가 물질

5

반응물 3

HCID 962WaterHCID 682631,1'-CarbonyldiimidazoleHCID 47396291-Acetyl-4-(2-hydroxyethyl)piperazine

생성물 1

HCID 218676622-(4-Acetyl-1-piperazinyl)ethyl 1H-imidazole-1-carboxylate수율 96%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of 1,1′-carbonyldiimidazole (5 g, 31 mmol) in DCM (200 mL) was treated with a solution of 1-[4-(2-hydroxyethyl)-1-piperazinyl]-1-ethanone (see step (i) above; 5 g, 29 mmol) in DCM (50 mL). The reaction mixture was stirred at rt overnight before water was added. The layers were separated, and the organic layer was washed with water, dried and concentrated in vacuo to yield 7.4 g (96%) of the title compound.

후처리

  1. additionwas added
  2. customThe layers were separated
  3. washthe organic layer was washed with water
  4. customdried
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-906156b8f442413eb9ef08f7b7eaf71f
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06559162B2

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