Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 411620생성일: 2026년 10월 26일
Omeprazole → 1-[(benzotriazol-1-yl)methyl]-6-methoxy-2-[[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
https://huagongshe.com/reaction/411620
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Omeprazole | HCID 4594 | — |
| 반응물 | 1-(Chloromethyl)-1H-benzotriazole | HCID 3328222 | — |
| 반응물 | 1-[(benzotriazol-1-yl)methyl]-5-methoxy-2-[[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole | HCID 18541198 | — |
| 반응물 | Sodium t-butoxide | HCID 23676156 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Chloroform methanol | HCID 21584188 | — |
| 생성물 | 1-[(benzotriazol-1-yl)methyl]-6-methoxy-2-[[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole | HCID 18541128 | — |
반응 단계
5-Methoxy-2-[[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole (172 mg) was dissolved in 20 ml of dichloromethane. Sodium tert-butoxide (55 mg) and 1-(chloromethyl)-1H-benzotriazole (85 mg) was added. The reaction mixture was stirred at 30° C. for 3 days. TLC analysis (developing solvent; chloroform-methanol 15:1) showed major one spot of 1-[(benzotriazol-1-yl)methyl]-5-methoxy-2-[[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole above 5-methoxy-2-[[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole. The titled product was purified by preparative thin layer chromatography. 195 mg of product, a mixture of 1-[(benzotriazol-1-yl)methyl]-5-methoxy-2-[[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole and 1-[(benzotriazol-1-yl)methyl]-6-methoxy-2-[[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole was obtained (3:2 ratio).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06559167B1 |
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| 출처 데이터셋 | uspto-grants-2003_05 |
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| ORD ID | ord-1b68d613025a437985ac12dc9d4fd244 |
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| 출처 메모 | uspto-grants-2003_05 |
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