Sodium Cyanide → (4R *,5R*)-5-(4-chloro-3-trifluoromethyl-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole

HRID 411640

반응식

HRID 411640 반응식
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].[S:14]([CH2:24][N+:25]#[C-:26])([C:17]1[CH:23]=[CH:22][C:20]([CH3:21])=[CH:19][CH:18]=1)(=[O:16])=[O:15].[C-]#N.[Na+]>>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C@H:6]2[O:7][CH:26]=[N:25][C@@H:24]2[S:14]([C:17]2[CH:23]=[CH:22][C:20]([CH3:21])=[CH:19][CH:18]=2)(=[O:16])=[O:15])=[CH:4][C:3]=1[C:10]([F:11])([F:12])[F:13]

참가 물질

4

반응물 3

HCID 8929Sodium CyanideHCID 1186424-Chloro-3-(trifluoromethyl)benzaldehydeHCID 161915Tosylmethyl isocyanide

생성물 1

HCID 69556945(4R *,5R*)-5-(4-chloro-3-trifluoromethyl-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole

실험 절차

In a manner analogous to Preparation 1, 4-chloro-3-(trifluoromethyl)benzaldehyde (0.31 g, 1.47 mmol), tosylmethylisocyanide (0.27 g, 1.40 mmol) and NaCN (6.9 mg, 0.14 mmol) gave the desired compound as a tan solid. MS(ES+) m/z 404.5 (M+H+).

출처 및 근거

ORD 기록
ord-2062fb24d3e14162a441c15b1be6598e
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06559172B1

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